doxylamine + pyridoxine (Resilient Cosmeceuticals Pvt. Ltd.)

MS DOS is a fixed-dose combination antiemetic medication developed by Resilient Cosmeceuticals, specifically indicated for the treatment of nausea and vomiting during pregnancy (NVP), commonly known as morning sickness. The formulation consists of doxylamine succinate, a first-generation antihistamine that acts as a competitive antagonist at the histamine H1 receptor, and pyridoxine hydrochloride (Vitamin B6), which serves as a metabolic cofactor. Doxylamine provides antiemetic effects through its action on the vestibular system and the chemoreceptor trigger zone, while pyridoxine has been clinically shown to reduce the severity of pregnancy-related nausea. The product is available in several variants, including **MS DOS Plus**, which incorporates folic acid for prenatal nutritional support, and **MS DOS OD**, a higher-strength formulation intended for once-daily administration. It is typically prescribed for pregnant women who do not respond to conservative management such as dietary and lifestyle changes.

Brand names

MS DOSMS DOS PlusMS DOS OD

Other names

doxylamine succinate and pyridoxine hydrochloride