drotaverine (Adorshea Bioceutics)

Drotaverine is a benzylisoquinoline derivative and a potent antispasmodic agent. It acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4), which leads to an increase in intracellular levels of cyclic adenosine monophosphate (cAMP) in smooth muscle cells. This mechanism results in the relaxation of smooth muscles across various organ systems, including the gastrointestinal, biliary, and urogenital tracts, as well as the uterus. Marketed by Adorshea Bioceutics under the brand name Adorta, it is primarily indicated for the relief of smooth muscle spasms and is also utilized in obstetric care for the management of preterm labor to facilitate cervical dilation. Unlike some other antispasmodics, drotaverine does not possess anticholinergic properties, which reduces the incidence of side effects such as dry mouth or blurred vision.

Brand names

Adorta

Other names

drotaverine hydrochloride