DTP-HB vaccine (Bio Farma)

The DTP-HB vaccine developed by Bio Farma is a quadrivalent combination vaccine designed to provide active immunization against diphtheria, tetanus, pertussis (whooping cough), and hepatitis B. It is a biological product containing purified diphtheria and tetanus toxoids, inactivated whole-cell Bordetella pertussis bacteria, and recombinant hepatitis B surface antigen (HBsAg) produced in yeast (Saccharomyces cerevisiae). The vaccine works by inducing the production of protective antibodies against the toxins of Corynebacterium diphtheriae and Clostridium tetani, the cellular components of B. pertussis, and the surface antigen of the Hepatitis B virus. It is typically adsorbed onto aluminum salts to enhance immunogenicity and is administered via intramuscular injection, primarily as part of pediatric immunization schedules.