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Drug intelligence / Profile preview
DTX-SPL8783 (Starpharma)
- Development stage
- Unknown
- Lead developer
- Starpharma
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
DTX-SPL8783 (also known as DEP-docetaxel) is a dendrimer–drug conjugate developed by Starpharma using its proprietary DEP® (Dendrimer Enhanced Product) platform. It consists of docetaxel molecules covalently attached to a dendrimer nanoparticle scaffold via a controlled-release linker. This nanotechnology-based formulation is designed to improve the therapeutic index of docetaxel by enhancing tumor targeting through the enhanced permeability and retention (EPR) effect, extending plasma half-life (40–60 hours), and reducing systemic toxicities such as neutropenia and hypersensitivity reactions compared to conventional docetaxel (Taxotere®). DTX-SPL8783 is currently being evaluated in Phase 1/2 clinical trials for the treatment of advanced solid tumors, including non-small cell lung cancer (NSCLC), both as a monotherapy and in combination with other agents like nintedanib.
- Other names
- DEP docetaxeldocetaxel dendrimer conjugate
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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