dulaglutide + sulfonylureas

Dulaglutide + sulfonylureas is a combination therapy used in adults with type 2 diabetes mellitus to improve glycemic control. **Dulaglutide** is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist administered once weekly by subcutaneous injection; it stimulates glucose-dependent insulin secretion, suppresses inappropriate glucagon secretion, and slows gastric emptying, resulting in reduced fasting and postprandial blood glucose levels. **Sulfonylureas** are small molecule oral antidiabetic drugs that act by stimulating pancreatic beta cells to increase insulin secretion, independent of plasma glucose concentration. The combination is often used where glycemic control is insufficient with either agent alone, and is recognized in guidelines for type 2 diabetes management. This combination is not a fixed single formulation but refers to concomitant use of separate medications from each class[3][7].