Drug intelligence / Profile preview

dust mite extract + fluticasone + methacholine

Development stage
Unknown
Lead developer
ALK Abelló
Modality
Small Molecules
Administration
Inhalation, Intranasal, Topical, Subcutaneous, Intradermal, Sublingual
01

Overview

This is a combination of three agents: - **Dust mite extract** is an allergen extract used primarily for allergy testing or immunotherapy, particularly in the diagnosis and management of allergic diseases such as asthma and allergic rhinitis. - **Fluticasone** is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory activity, commonly used to treat asthma, allergic rhinitis, and various inflammatory skin conditions. It acts mainly by activating the glucocorticoid receptor to suppress inflammation[2][4]. - **Methacholine** is a cholinergic agonist used almost exclusively as a diagnostic agent in bronchial challenge tests to assess airway hyperresponsiveness (e.g., for diagnosing asthma). It induces bronchoconstriction by stimulating muscarinic receptors in airway smooth muscle[7]. This combination does not represent an approved pharmaceutical product but may be encountered together in clinical research or diagnostic protocols involving allergen exposure (dust mite), anti-inflammatory treatment (fluticasone), and bronchoprovocation testing (methacholine).

Other names
Dust mite extract, Fluticasone, Methacholine
02

Targets

GR (Glucocorticoid receptor)CHRM3 (M3)

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