Drug intelligence / Profile preview

dutasteride + tadalafil

Development stage
Phase 3
Lead developer
Dongkook Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Dutasteride + tadalafil is a fixed-dose combination of two small molecule drugs used primarily in the management of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) in men. Dutasteride is a 5-alpha-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone, leading to reduced prostate volume and improvement in urinary symptoms. Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor that increases blood flow by relaxing smooth muscle, improving both LUTS and erectile function. The combination has been shown to be effective and safe for male patients with moderate-to-severe LUTS/ED, though response may be diminished in those with certain prostate anatomical features[1][3]. This combination does not have a unique brand name formulation widely marketed as of now.

Other names
DKF-313DKF313DKF 313
02

Targets

SRD5A2 (Steroid 5-alpha-reductase type II)PDE5 (Phosphodiesterase 5A)SRD5A1 (Steroid 5-alpha-reductase type 1)

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