Drug intelligence / Profile preview

duvie + sitagliptin

Development stage
Unknown
Lead developer
Chong Kun Dang Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Duvie + Januvia is a combination therapy for type 2 diabetes mellitus consisting of imeglimin (brand name Duvie) and sitagliptin (brand name Januvia). Imeglimin is an oral antidiabetic agent that acts by improving mitochondrial function and enhancing both insulin secretion and sensitivity. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases incretin levels, thereby stimulating insulin release and decreasing glucagon secretion in a glucose-dependent manner. This combination targets multiple pathophysiological defects in type 2 diabetes to improve glycemic control.

Other names
duvie + januviaimeglimin + sitagliptin
02

Targets

DPP-4 (Dipeptidyl Peptidase-IV)

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