e-e-desogestrel + e-e-etonogestrel

This is a combination of two progestins, desogestrel and etonogestrel, both in their 11-methylene (E-E) forms. Desogestrel is a third-generation synthetic progestin used primarily in oral contraceptives, where it acts as a progesterone receptor agonist to inhibit ovulation and alter cervical mucus and endometrial lining to prevent pregnancy[6][8]. Etonogestrel is the biologically active metabolite of desogestrel and is also used as a contraceptive agent, most notably in subdermal implants or vaginal rings[5][7]. Both drugs act by suppressing the hypothalamic-pituitary-gonadal axis, thereby inhibiting gonadotropin secretion (luteinizing hormone and follicle-stimulating hormone), which prevents ovulation. They also increase cervical mucus viscosity to impede sperm penetration and induce endometrial changes that reduce the likelihood of implantation[2][3][7]. This specific combination (desogestrel + etonogestrel) does not correspond to any approved pharmaceutical product; typically, each drug is combined with an estrogen such as ethinyl estradiol for contraceptive use.