Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
E-PRF + rhBMP-2
- Development stage
- Preclinical
- Modality
- Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Recombinant Proteins and Enzymes
- Administration
- Surgical Implantation, Local Implantation
01
Overview
E-PRF + rhBMP-2 is a combination therapy consisting of endogenous platelet-rich fibrin (E-PRF) and recombinant human bone morphogenetic protein 2 (rhBMP-2). E-PRF is an autologous blood-derived biomaterial rich in platelets and growth factors, used to promote tissue regeneration. RhBMP-2 is a recombinant form of the naturally occurring BMP-2 protein, which induces osteogenic differentiation and stimulates new bone formation by binding to specific receptors on mesenchymal stem cells. The combination aims to leverage the scaffold properties and growth factor content of E-PRF with the potent osteoinductive effect of rhBMP-2 for enhanced bone regeneration. This approach has been investigated primarily in dental, maxillofacial, and orthopedic applications for critical-sized bone defects or conditions such as medication-related osteonecrosis of the jaw (MRONJ)[1][7].
- Other names
- E-PRF and recombinant human bone morphogenetic protein 2Endogenous Platelet-Rich Fibrin plus rhBMP-2
02
Targets
BMPR2 (Bone morphogenetic protein receptor type II)ACVR1 (Activin receptor type I)
Beyond the preview
Go deeper on E-PRF + rhBMP-2.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on E-PRF + rhBMP-2.