E5555 + diltiazem

E5555 is an investigational drug (not described in the provided sources; based on external knowledge it is a selective protease-activated receptor-1 [PAR-1] antagonist developed for cardiovascular indications). Diltiazem is a non-dihydropyridine calcium channel blocker used to treat hypertension (high blood pressure), angina (chest pain), and certain heart arrhythmias. It works by inhibiting the influx of calcium ions into cardiac and vascular smooth muscle cells during depolarization. This action relaxes blood vessels and reduces the workload on the heart while increasing coronary blood flow. Diltiazem is approved for use as an antihypertensive agent and antianginal agent[1][2][3][4][5][6].

Brand names

CardizemCardizem CDCardizem LACartia XTDilacor XRDilt-CDDiltia XTDilt-XRDiltzacMatzim LATaztia XTTiazac

Other names

benzothiazepine derivative (for diltiazem)