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EBV-specific T-cell lines (Delisle)
- Development stage
- Unknown
- Lead developer
- Hôpital Maisonneuve-Rosemont
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
EBV-specific T-cell lines (EBV-CTLs) are an investigational adoptive cellular immunotherapy developed by Dr. Jean-Sebastien Delisle at Hôpital Maisonneuve-Rosemont. This therapy involves the ex vivo expansion and 'education' of T lymphocytes to recognize and eliminate cells infected with the Epstein-Barr virus (EBV). The T-cell lines are generated using peripheral blood mononuclear cells from either the patient (autologous) or a matched/partially matched related donor (allogeneic), which are then stimulated with EBV-specific peptides. The therapy is primarily intended for patients with refractory EBV reactivation, EBV-related lymphoma, or post-transplant lymphoproliferative disorder (PTLD) following hematopoietic stem cell or solid organ transplantation. It is currently being evaluated in a Phase I/II clinical trial (NCT02580539).
- Other names
- EBV-CTLsEpstein-Barr virus-specific cytotoxic T lymphocytesPeptide-stimulated T cells
02
Targets
EBNA1 (Epstein-Barr virus latency proteins)
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