econazole nitrate + benzydamine hydrochloride

A fixed-dose combination of econazole nitrate and benzydamine hydrochloride is formulated as a vaginal pessary for the treatment of vulvovaginal candidiasis and associated symptoms. Econazole nitrate is an imidazole antifungal agent that inhibits lanosterol 14-α demethylase, disrupting ergosterol synthesis in fungal cell membranes, leading to increased permeability and cell death. Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug (NSAID) with local anesthetic, analgesic, anti-inflammatory, and membrane-stabilizing properties; it acts by inhibiting pro-inflammatory cytokines and stabilizing cellular membranes. The combination aims to provide both antifungal efficacy (from econazole) and rapid symptomatic relief (from benzydamine). Systemic absorption from intravaginal administration is low[1][2][5].

Other names

econazole and benzydamine fixed-dose combination