Drug intelligence / Profile preview

econazole nitrate + triamcinolone acetonide

Development stage
Unknown
Lead developer
Johnson & Johnson
Modality
Small Molecules
Administration
Topical
01

Overview

Stenide is a topical fixed-dose combination cream developed by Navana Pharmaceuticals, containing the broad-spectrum imidazole antifungal econazole nitrate (1%) and the synthetic corticosteroid triamcinolone acetonide (0.1%). Econazole nitrate exerts its antifungal effect by inhibiting lanosterol 14-alpha demethylase (CYP51), thereby disrupting ergosterol synthesis and compromising fungal cell membrane integrity. Triamcinolone acetonide acts as a glucocorticoid receptor agonist, suppressing local inflammatory responses, reducing capillary permeability, and alleviating symptoms such as redness, swelling, and itching. Stenide is indicated for the short-term treatment of inflammatory dermatomycoses and eczematous skin conditions complicated by or threatened by bacterial or fungal infections, including tinea pedis, tinea corporis, tinea cruris, and diaper dermatitis.

Brand names
StenideStenide Cream
Other names
econazole + triamcinoloneeconazole and triamcinoloneeconazole nitrate + triamcinolone acetonideeconazole nitrate and triamcinolone acetonidetriamcinolone + econazoletriamcinolone and econazoletriamcinolone acetonide + econazole nitratetriamcinolone acetonide and econazole nitrate
02

Targets

CYP51A1 (Sterol 14α-demethylase)GR (Glucocorticoid receptor)PXR (Pregnane X receptor)

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