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edetate calcium disodium + succimer + magnesium sulfate + multivitamin
- Development stage
- Unknown
- Lead developer
- University of Texas MD Anderson Cancer Center
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
This intervention is a metal detoxification regimen being evaluated at the M.D. Anderson Cancer Center for patients with advanced myeloid malignancies, including acute myeloid leukemia (AML), myeloproliferative neoplasm in blast phase (MPN-BP), and chronic myeloid leukemia in blast phase (CML-BP). The regimen consists of the chelating agents edetate calcium disodium (Ca-EDTA) and succimer (DMSA), supplemented with magnesium sulfate and a multivitamin. The therapeutic hypothesis is that toxic metal accumulation in the bone marrow may contribute to leukemogenesis or resistance to standard chemotherapy; therefore, removing these metals via chelation may sensitize cancer cells to treatment and improve clinical outcomes.
- Other names
- Metal detoxification therapyCa-EDTA + DMSA + Magnesium Sulfate + Multivitamin
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