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Drug intelligence / Profile preview
EGFR(V)-EDV-PNU
- Development stage
- Phase 2
- Lead developer
- Engeneic
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
EGFR(V)-EDV-PNU (also known as EGFR-VEDVsPNU or E-EDV-D682) is an investigational cancer therapy developed by EnGeneIC Pty Limited. It utilizes the EnGeneIC Dream Vector (EDV) platform, which consists of non-pathogenic, bacterially-derived nanocells (derived from Salmonella). These nanocells are loaded with PNU-159682, a super-cytotoxic anthracycline derivative, and are targeted to the Epidermal Growth Factor Receptor (EGFR) using a bispecific antibody based on the panitumumab sequence. This delivery system is designed to selectively release the cytotoxic payload within EGFR-expressing tumor cells while minimizing systemic toxicity. In clinical trials, it is typically administered intravenously in combination with non-targeted EDVs containing an immunomodulatory 60mer oligonucleotide adjuvant to stimulate an anti-tumor immune response.
- Other names
- EGFR-targeted EDV nanocells carrying PNU-159682
02
Targets
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