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EGFRvIII CAR-T (Guangzhou FineImmune Biotechnology)
- Development stage
- Preclinical
- Lead developer
- Guangzhou FineImmune Biotechnology
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
EGFRvIII CAR-T is an autologous chimeric antigen receptor (CAR) T-cell therapy developed by Guangzhou FineImmune Biotechnology for the treatment of glioblastoma. The therapy utilizes the company's SUPER CAR-T platform to engineer T cells that specifically target the Epidermal Growth Factor Receptor variant III (EGFRvIII), a tumor-specific mutation frequently expressed in glioblastoma multiforme but absent in healthy tissues. By binding to EGFRvIII-expressing cells, the CAR-T cells initiate targeted cytotoxicity to eliminate malignant cells while minimizing off-target effects on normal brain tissue.
- Other names
- EGFRvIII-targeted CAR-TEGFRvIII CAR-T cell therapy
02
Targets
EGFRvIII (Epidermal growth factor receptor variant III)
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