Drug intelligence / Profile preview

eicosapentaenoic acid + gamma-linolenic acid + vitamins + minerals

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

This agent is a **combination dietary supplement** containing **eicosapentaenoic acid** (EPA), **gamma-linolenic acid** (GLA), various **vitamins**, and **minerals**. EPA is an omega-3 fatty acid known primarily for its ability to reduce triglyceride levels, prevent excessive blood clotting, and exert anti-inflammatory effects. GLA is an omega-6 fatty acid that serves as a precursor to prostaglandin E1 (PGE1), which has anti-inflammatory, antithrombotic, and lipid-lowering properties. The combination of EPA and GLA is utilized to synergistically modulate the production of pro-inflammatory lipid mediators (eicosanoids); EPA helps counteract the potential accumulation of pro-inflammatory arachidonic acid metabolites produced as a result of GLA supplementation. Supplementation with both EPA and GLA has been studied to help manage chronic inflammatory disorders, cardiovascular health, and potentially bone metabolism. When delivered together with vitamins and minerals, this combination is used as a dietary supplement for supporting general health, though it may also be found formulated for more specific health purposes such as managing dry eye or providing anti-inflammatory support[1][3][5][7].

02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)15-LOX (Lysyl Oxidase)FADS1 (Fatty acid desaturase 1)

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