ellagic acid + pomegranate extract

Ellagic acid + pomegranate extract is a combination dietary supplement consisting of ellagic acid, a polyphenolic antioxidant, and pomegranate (Punica granatum) extract, which is standardized to contain high levels of ellagitannins and other polyphenols. Pomegranate extract is rich in punicalagin and other ellagitannins that are metabolized in the body to produce ellagic acid. This combination exhibits potent antioxidant, anti-inflammatory, and potential anticancer properties. Mechanistically, these compounds act by scavenging free radicals, modulating inflammatory pathways (such as NF-κB), downregulating pro-inflammatory cytokines (including iNOS and TNF-α), inhibiting matrix metalloproteinases involved in cancer metastasis (MMP-2/-9), suppressing STAT3 phosphorylation, and reducing oxidative stress. Clinical studies have explored their use for conditions such as prostate cancer, chronic colonic inflammation, asthma symptom relief, skin hyperpigmentation from UV exposure, and general antioxidant support[2][3][4][5][6][9].