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eloralintide + tirzepatide
- Development stage
- Phase 3
- Lead developer
- Eli Lilly
- Modality
- Small Molecules, Recombinant Proteins and Enzymes, Peptides
- Administration
- Subcutaneous
01
Overview
**Eloralintide + tirzepatide** is an investigational combination drug being developed for obesity and weight management, currently in clinical trials. Eloralintide is an amylin analog designed to mimic the metabolic hormone amylin, which controls appetite and gastric emptying; it is being developed as a next-generation therapy for obesity, both as monotherapy and in combination with other agents. Tirzepatide is a dual agonist of the glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) receptor, approved for type 2 diabetes, obesity, and weight loss. The combination is under investigation to determine if the addition of eloralintide to tirzepatide can achieve greater, more sustained weight loss compared to single-agent therapy. Both drugs are administered subcutaneously. The developer is Eli Lilly and Company[1][3][5][7].
- Other names
- tirzepatide
02
Targets
AMY (Pancreatic alpha-amylase)AMY3 (Amylin receptor 3)GIPR (Gastric inhibitory polypeptide receptor)GLP1R (GLP-1R)CALCR (Calcitonin receptor)AMY receptor (Calcitonin receptor (with ramps))
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