enalapril + folic acid + amlodipine

Enalapril + folic acid + amlodipine is a fixed-dose combination drug containing three active ingredients: - **Enalapril** is an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced aldosterone secretion. - **Folic acid** (vitamin B9) is included for its ability to lower plasma homocysteine levels, which are associated with increased cardiovascular risk. Folic acid supplementation in hypertensive patients with hyperhomocysteinemia has been shown to further reduce the risk of stroke and cardiovascular events when combined with antihypertensive therapy. - **Amlodipine** is a dihydropyridine calcium channel blocker that reduces blood pressure by inhibiting calcium influx into vascular smooth muscle cells, resulting in vasodilation. This combination targets both hypertension and elevated homocysteine levels, conditions that synergistically increase the risk of stroke and other cardiovascular events. Clinical studies have demonstrated that combining these agents can provide additive or synergistic effects on lowering blood pressure and reducing total homocysteine concentrations compared to monotherapy or dual combinations[1][2][3]. The combination may be particularly beneficial for patients who require comprehensive management of hypertension complicated by hyperhomocysteinemia.

Other names

enalapril + amlodipine + folic acidenalapril maleate + amlodipine besylate + folic acid