Drug intelligence / Profile preview

enalapril + hydrochlorothiazide

Development stage
Unknown
Lead developer
Merck
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Oral
01

Overview

Enalapril + hydrochlorothiazide is a fixed-dose combination oral medication used to treat high blood pressure (hypertension). It contains two active ingredients with complementary mechanisms of action. Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure by blocking the formation of angiotensin II, a substance that causes blood vessels to constrict; this results in vasodilation and reduced workload on the heart. Hydrochlorothiazide is a thiazide diuretic ("water pill") that reduces blood pressure by increasing renal excretion of sodium and water, thereby decreasing plasma volume. The combination provides additive antihypertensive effects and may be used when monotherapy with either agent alone does not adequately control blood pressure[1][2][3][4][5][8].

Brand names
Vaseretic
Other names
enalapril/hydrochlorothiazideenalapril and hydrochlorothiazide
02

Targets

ACE (Angiotensin Converting Enzyme)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

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