enalapril + losartan

Enalapril + losartan is a fixed-dose combination of two antihypertensive agents, enalapril and losartan. Enalapril is an angiotensin-converting enzyme (ACE) inhibitor, while losartan is an angiotensin II receptor blocker (ARB). This combination targets the renin-angiotensin system at two different points, resulting in additive or synergistic effects on blood pressure reduction and cardiovascular protection. The dual blockade can be more effective than monotherapy with either agent alone for improving myocardial function and lowering blood pressure, particularly in patients with hypertension, heart failure, or diabetic kidney disease. The main mechanisms involve inhibition of ACE by enalapril (reducing conversion of angiotensin I to angiotensin II) and antagonism of the angiotensin II type 1 receptor by losartan (blocking vasoconstrictive and aldosterone-secreting effects). Common side effects include dizziness, cough, hyperkalemia, nausea, headache, weakness, and hypotension[1][2][3][5].

Other names

angiotensin-converting enzyme inhibitor + angiotensin-II type 1 receptor blockerACE inhibitor + ARBACEI + ARBenalapril and losartan combination