enoxaparin + acenocoumarol

This is a combination of two anticoagulant drugs, enoxaparin and acenocoumarol, used to prevent and treat thromboembolic disorders such as deep vein thrombosis (DVT) and pulmonary embolism. Enoxaparin is a low molecular weight heparin that acts by binding to antithrombin III, enhancing its inhibition of factor Xa and, to a lesser extent, factor IIa (thrombin), thereby preventing clot formation[6][10]. Acenocoumarol is an oral vitamin K antagonist that inhibits vitamin K reductase, reducing the synthesis of active vitamin K-dependent clotting factors II, VII, IX, and X[1]. The combination increases the risk of bleeding due to additive anticoagulant effects but may be used in clinical settings where rapid onset (from enoxaparin) is needed while transitioning to or overlapping with oral therapy (acenocoumarol)[3][4][5].

Brand names

Sintrom

Other names

low molecular weight heparin + coumarin derivative anticoagulant