enoxaparin sodium + andexanet alfa

This is a **combination of two agents**: **enoxaparin sodium** (a low-molecular-weight heparin anticoagulant) and **andexanet alfa** (a recombinant modified human factor Xa decoy protein). Enoxaparin sodium works by enhancing antithrombin-mediated inhibition of coagulation factors (mainly factor Xa and to a lesser degree factor IIa/thrombin), exerting its anticoagulant effect. Andexanet alfa is used as an antidote/reversal agent for bleeding due to factor Xa inhibitors, including enoxaparin. It acts as a factor Xa decoy, binding and sequestering factor Xa inhibitors, rapidly neutralizing their anticoagulant activity and restoring coagulation in cases of major or uncontrolled bleeding[2][4][5]. This combination is not a branded coformulation but refers to the administration of both drugs, usually with andexanet alfa given to reverse life-threatening anticoagulation from enoxaparin[4][5].