EnvDNA + PolyEnv1 + EnvPro

EnvDNA + PolyEnv1 + EnvPro is a combination investigational HIV vaccine regimen designed as a multi-envelope, prime-boost strategy. The regimen consists of three components: - **EnvDNA** (a DNA-based vaccine encoding HIV envelope proteins) - **PolyEnv1** (a polyvalent vaccinia virus vector expressing multiple HIV-1 envelope antigens) - **EnvPro** (a recombinant protein component containing HIV envelope proteins) This combination aims to stimulate both cellular and humoral immune responses against diverse strains of HIV by sequentially priming and boosting the immune system with different forms of the viral envelope antigen. The approach is intended to enhance immunogenicity compared to single-component vaccines. Developed primarily for prophylactic use in preventing HIV infection, this regimen has been evaluated in early-phase clinical trials for safety and immunogenicity[1][2][3][7].