Drug intelligence / Profile preview

ephedra + apricot kernel

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Ephedra + apricot kernel is a traditional herbal drug combination commonly used in Chinese medicine, most notably as part of multi-herb formulas such as Ma Xing Shi Gan Tang (Ephedra Apricot Kernel Gypsum and Licorice Decoction). Ephedra (ma huang) contains alkaloids like ephedrine that act as bronchodilators and stimulants, while apricot kernel (xing ren), particularly the bitter variety, contains amygdalin and is used to relieve cough and wheezing. The combination is primarily indicated for respiratory conditions such as cough, asthma, bronchitis, pneumonia, and symptoms associated with lung heat or wind-heat/cold attacks. Mechanistically, Ephedra stimulates beta-adrenergic receptors leading to bronchodilation and increased lung ventilation; Apricot kernel helps suppress cough by dispersing lung qi downward. In TCM theory, this pair synergistically invigorates lung qi and relieves wheezing. Modern studies suggest that combining these herbs may modulate the absorption of active alkaloids from Ephedra—potentially reducing toxicity while maintaining efficacy[1][2][3][4].

Other names
ma huang + xing renephedra + bitter apricot kernel
02

Targets

ADRB1 (β1)ADRB3 (β3)ADRB2 (β2)

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