Drug intelligence / Profile preview

Epidiferphane + taxane

Development stage
Unknown
Lead developer
University of Florida
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Epidiferphane + taxane is a combination therapy being investigated by the University of Florida for the treatment of breast cancer. The regimen consists of standard-of-care taxane chemotherapy (such as paclitaxel, docetaxel, or nab-paclitaxel) and Epidiferphane, a multi-ingredient nutritional supplement containing phytochemicals derived from turmeric (curcumin), broccoli (sulforaphane), and green tea (EGCG). The primary objective of adding Epidiferphane to the chemotherapy regimen is to mitigate common taxane-induced toxicities, specifically peripheral neuropathy and anemia. By reducing these side effects, the supplement aims to prevent dose reductions and treatment delays, thereby maintaining the relative dose intensity (RDI) of the chemotherapy and potentially improving overall tumor response and patient survival outcomes.

Brand names
Epidiferphane
Other names
Epidiferphane and Taxanes
02

Targets

TUBB (Tubulin (alpha and beta subunits))

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