ergotamine + caffeine + acetylsalicylic acid + homatropine

A combination medication containing **ergotamine, caffeine, acetylsalicylic acid (aspirin), and homatropine**. This oral formulation is indicated for the **acute treatment of migraine and cluster headaches**. - **Ergotamine** is an ergot alkaloid that acts as a vasoconstrictor, reducing dilation in cranial blood vessels. - **Caffeine** enhances the absorption and vasoconstrictive effect of ergotamine. - **Acetylsalicylic acid (aspirin)** is a nonsteroidal anti-inflammatory drug (NSAID) that provides analgesic and anti-inflammatory effects. - **Homatropine** is an anticholinergic agent typically added at very low doses to reduce excessive cholinergic (gastrointestinal and central nervous system) side effects. The combination aims to relieve headache pain through multiple mechanisms: vascular constriction, reduction in neurogenic inflammation, central analgesia, and mitigation of certain side effects.