Drug intelligence / Profile preview

erlotinib + panobinostat

Development stage: Unknown
Lead developer: Novartis
Modality: Small Molecules
Administration: Oral

Overview

A combination therapy consisting of erlotinib, an EGFR tyrosine kinase inhibitor, and panobinostat, a histone deacetylase (HDAC) inhibitor. This combination has been investigated for its potential synergistic effects in treating advanced aerodigestive tract tumors, particularly non-small cell lung cancer (NSCLC) and head and neck cancer. The combination works by simultaneously inhibiting EGFR signaling and modifying histone acetylation to enhance antiproliferative activity.

Targets

HDAC (HDAC family)EGFR (Epidermal growth factor receptor)

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