Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
erythromycin + metoclopramide
- Development stage
- Unknown
- Lead developer
- Guangdong Provincial People's Hospital
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
The combination of erythromycin and metoclopramide is a dual-prokinetic therapy used primarily in the intensive care unit (ICU) to manage gastric feeding intolerance in critically ill patients. Erythromycin, a macrolide antibiotic, acts as a motilin receptor agonist, mimicking the effects of the endogenous hormone motilin to induce phase III migrating motor complex-like contractions in the stomach. Metoclopramide is a benzamide that functions as a dopamine D2 receptor antagonist and a 5-HT4 receptor agonist, which enhances upper gastrointestinal motility and accelerates gastric emptying. When used together, these agents provide a synergistic effect on gastric motility, often succeeding in patients who fail monotherapy. This specific combination has been extensively studied by researchers at the Guangdong Provincial People's Hospital and the Guangdong Academy of Medical Sciences to optimize enteral nutrition delivery in patients with critical illness.
- Other names
- erythromycin and metoclopramide combinationmetoclopramide and erythromycin
02
Targets
DRD2 (Dopamine D2 Receptor)HTR4 (5-Hydroxytryptamine receptor 4)MLNR (Human motilin receptor)HTR3A (5-hydroxytryptamine receptor 3A)
Beyond the preview
Go deeper on erythromycin + metoclopramide.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on erythromycin + metoclopramide.