Drug intelligence / Profile preview

escitalopram + golimumab

Development stage
Unknown
Lead developer
Lundbeck
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Subcutaneous, Intravenous
01

Overview

This is a combination of two drugs with distinct mechanisms and indications: - **Escitalopram** is a selective serotonin reuptake inhibitor (SSRI) used primarily for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other psychiatric conditions. It works by selectively inhibiting the serotonin transporter (SERT), increasing serotonin levels in the brain to improve mood and reduce anxiety[1][7]. - **Golimumab** is a human monoclonal antibody that inhibits tumor necrosis factor alpha (TNFα). It is indicated for various inflammatory disorders including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Golimumab binds both soluble and transmembrane TNFα to suppress inflammation[2]. There are no known approved pharmaceutical products or clinical trials specifically combining escitalopram with golimumab as a fixed-dose or co-packaged therapy. Each drug retains its individual mechanism of action when used together.

Brand names
Cipralex
Other names
S(+)-Citalopram(S)-CitalopramEscitalopramumCNTO 148CNTO148CNTO-148
02

Targets

SERT allosteric site (Serotonin transporter allosteric site)KCNH2 (Voltage-gated potassium channel subfamily H member 2)DAT (Dopamine plasma membrane transport protein)TNFA (Tumor necrosis factor alpha (soluble))NET (Norepinephrine Transporter)

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