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escitalopram + memantine
- Development stage
- Phase 4
- Lead developer
- Lundbeck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Escitalopram + memantine is a combination of two small molecule drugs used in clinical research for the treatment of major depressive disorder (MDD) in older adults with subjective memory complaints. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the brain by inhibiting its reuptake, thereby improving mood and alleviating symptoms of depression. Memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist that modulates glutamatergic neurotransmission and is primarily used to treat moderate-to-severe Alzheimer's disease due to its neuroprotective effects. The combination has been studied for its potential to improve both depressive symptoms and cognitive function in geriatric patients, showing greater improvements in executive functioning, delayed recall, gray matter volume, and cortical thickness compared to escitalopram alone[1][2][3][5].
- Other names
- escitalopram and memantineESC/MEM
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)SERT (Sodium-dependent serotonin transporter)
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