escitalopram + risperidone

Escitalopram + risperidone is a combination of two pharmaceutical drugs used primarily in psychiatric practice. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the brain by inhibiting its reuptake, thereby improving mood and anxiety symptoms. Risperidone is an atypical antipsychotic that acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors, reducing psychotic symptoms such as delusions and hallucinations. The combination has been studied for use in treating positive and negative symptoms of schizophrenia, especially when depressive or cognitive symptoms are present. Co-administration may enhance dopaminergic and serotonergic neurotransmission more effectively than either drug alone[2]. However, this combination carries risks including increased potential for QT prolongation (irregular heart rhythm), additive central nervous system depression, impairment of judgment/psychomotor skills, and pharmacokinetic interactions due to CYP2D6 inhibition by escitalopram leading to higher risperidone levels[1][3][4].