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esketamine hydrochloride + hydromorphone
- Development stage
- Unknown
- Lead developer
- Second Affiliated Hospital of Zhejiang University School of Medicine
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Esketamine hydrochloride + hydromorphone is a combination analgesic regimen being investigated by the Second Affiliated Hospital, School of Medicine, Zhejiang University for the management of postoperative pain, anxiety, and depression in patients undergoing tumor surgery. Esketamine is the S-enantiomer of ketamine and acts primarily as a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, providing both analgesic and rapid-acting antidepressant effects. Hydromorphone is a potent semi-synthetic opioid that acts as an agonist at the mu-opioid receptor to provide systemic analgesia. This combination is typically administered via a patient-controlled analgesia (PCA) pump to optimize pain control while potentially reducing the incidence of postoperative mood disorders in cancer patients.
- Other names
- esketamine + hydromorphoneesketamine hydrochloride and hydromorphone combination
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)MOR (Mu opioid receptor)
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