esmolol + sodium nitroprusside

**Esmolol + sodium nitroprusside** is a combination used intravenously for acute cardiovascular management, particularly perioperative and intraoperative blood pressure and heart rate control. - **Esmolol** is a cardioselective beta-1 adrenergic receptor antagonist, acting as a rapid-onset, short-duration beta-blocker to reduce heart rate and suppress sympathetic stimulation[5]. - **Sodium nitroprusside** is a potent direct vasodilator that increases nitric oxide bioavailability, thus causing rapid and short-acting arterial and venous dilation, resulting in decreased blood pressure. This admixture is compatible and stable for at least 24 hours under protected conditions[1][4]. In clinical settings, esmolol is often used to counteract the reflex tachycardia induced by sodium nitroprusside during induced hypotension or controlled hypotensive anesthesia[2].

Other names

esmolol hydrochloride + sodium nitroprusside