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esmolol + sodium nitroprusside + norepinephrine
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination therapy consisting of esmolol (a selective beta-1 blocker), sodium nitroprusside (a vasodilator), and norepinephrine (a vasopressor). This combination is used in critical care settings to manage hemodynamics, particularly in septic shock patients. Esmolol provides heart rate control, sodium nitroprusside offers vasodilation, and norepinephrine maintains blood pressure through vasoconstriction. The combination allows for balanced hemodynamic management with potentially improved outcomes compared to single-agent therapy.
- Other names
- esmolol + NPS + NORMAPAS trial medicationsesmolol + sodium nitroprusside + norepinephrine-Hospital de Clinicas de Porto Alegre-acute ischemic stroke
02
Targets
sGC (Soluble Guanylyl Cyclase)ADRA2A (α2A)ADRA1A (α1A)ADRB1 (β1)
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