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This is not a fixed-dose combination product but rather two separate proton pump inhibitors (PPIs). Esomeprazole (Nexium) and pantoprazole (Protonix) are individual medications that work by decreasing acid secretion in the stomach through inhibition of the proton pump enzymes. Clinical studies have shown that 40 mg of pantoprazole and 40 mg of esomeprazole are equally effective for healing esophageal lesions and relieving GERD-related symptoms.
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