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esomeprazole + tripotassium dicitrate bismuthate + tetracycline + levofloxacin
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A quadruple therapy combination used for the treatment of Helicobacter pylori infection, particularly as a second-line or rescue treatment. This regimen combines a proton pump inhibitor (esomeprazole), bismuth (tripotassium dicitrate bismuthate), and two antibiotics (tetracycline and levofloxacin) to effectively eradicate H. pylori bacteria. Clinical studies have shown this combination achieves higher eradication rates compared to other rescue therapies, particularly for patients who have failed first-line treatments.
- Other names
- tetracycline-levofloxacin quadruple therapyTL quadruple therapy
02
Targets
Bacterial RibosomeATP4A (Potassium–transporting ATPase alpha chain 1)Topo IV (Bacterial Topoisomerase IV)DNA gyrase
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