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estradiol + dydrogesterone
- Development stage
- Phase 4
- Lead developer
- Abbott
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Estradiol + dydrogesterone is a fixed-dose combination of two hormones used in menopausal hormone therapy (HRT). Estradiol is a natural estrogen that helps restore declining estrogen levels in postmenopausal women, alleviating symptoms such as hot flashes and preventing osteoporosis. Dydrogesterone is a synthetic progestin added to counteract the risk of endometrial hyperplasia and cancer associated with unopposed estrogen therapy. The combination provides effective relief from climacteric symptoms and maintains bone mineral density while offering endometrial protection. It is administered orally and marketed under several brand names worldwide for use in postmenopausal women who have not undergone hysterectomy[1][2][3][4][5].
- Brand names
- FemostonClimastonFemaston
- Other names
- estradiol/dydrogesteroneE2/DYDdydrogesterone + estradiol
02
Targets
ESR1 (ERα)PR (Progesterone receptor)
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