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estradiol + progesterone (Women's Hormone Network)
- Development stage
- Unknown
- Lead developer
- TherapeuticsMD
- Modality
- Small Molecules
- Administration
- Transdermal, Topical
01
Overview
Estradiol + progesterone (Women's Hormone Network) refers to a compounded hormone replacement therapy (HRT) regimen utilizing bio-identical hormones in a transdermal cream. This specific protocol, studied by the Women's Hormone Network, employs a rhythmic dosing schedule designed to mimic the natural hormonal fluctuations of a 28-day menstrual or lunar cycle. By varying the doses of estradiol and progesterone daily, the therapy aims to restore physiologic hormone levels in peri- and postmenopausal women. The primary goals are to alleviate menopausal symptoms—such as hot flashes, night sweats, and mood disturbances—while supporting bone mineral density and cognitive health. Unlike static-dose HRT, this rhythmic approach is intended to provide a more natural endocrine environment, potentially reducing the side effects associated with constant hormone levels.
- Other names
- Compounded topical estradiol and compounded topical progesteroneRhythmic Bio-identical Hormone Replacement
02
Targets
PR (Progesterone receptor)ESR1 (ERα)GPER1 (G protein-coupled estrogen receptor 1)ESR2 (ERβ)
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