estradiol valerate + ethinylestradiol + traditional chinese medicine

estradiol valerate + ethinylestradiol + traditional chinese medicine refers to an integrative therapeutic regimen developed and extensively studied by the Obstetrics and Gynecology Hospital of Fudan University for managing diminished ovarian reserve (DOR) and associated infertility. This combination therapy typically utilizes a sequential or concurrent administration of Western hormonal agents—specifically estradiol valerate (a prodrug of 17β-estradiol) and ethinylestradiol (often provided as ethinylestradiol/cyproterone acetate)—alongside Traditional Chinese Medicine (TCM), most frequently the Kun-Tai capsule (Kuntai Wan). The mechanism of action is multi-targeted: the exogenous estrogens act as agonists at estrogen receptors (ERα and ERβ) to provide negative feedback on the hypothalamus and pituitary, thereby reducing pathologically elevated follicle-stimulating hormone (FSH) levels and stabilizing the endocrine environment. Simultaneously, the TCM component is hypothesized to improve ovarian blood flow, mitigate oxidative stress in the follicular microenvironment, and enhance ovarian responsiveness to gonadotropins. This synergistic approach aims to restore regular menses, improve antral follicle count (AFC), and enhance pregnancy outcomes in patients with declining ovarian function.

Other names

Kuntai capsule + HRTTCM-HRT sequential therapyestradiol valerate + ethinylestradiol cyproterone + Kuntai capsule