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estradiol valerate + levonorgestrel
- Development stage
- Unknown
- Lead developer
- Bayer HealthCare Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral (Klimonorm), Transdermal Patch (Climara Pro)
01
Overview
Estradiol valerate + levonorgestrel is a combined hormone therapy used primarily for menopausal hormone replacement. It contains estradiol valerate, an estrogen, and levonorgestrel, a progestin. The combination is used to manage symptoms of menopause such as hot flashes, vaginal atrophy, and to prevent osteoporosis. It works by supplementing the body with hormones that decline during menopause. Estrogen acts on estrogen receptors to alleviate menopausal symptoms and protect bone density; progestin (levonorgestrel) protects the endometrium from hyperplasia caused by unopposed estrogen[1][4][5].
- Brand names
- KlimonormClimara Pro
- Other names
- 克龄蒙
02
Targets
ESR1 (ERα)PR (Progesterone receptor)ESR2 (ERβ)
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