estrogens + testosterone

"estrogens + testosterone" refers to a combination hormonal treatment regimen used in gender-affirming hormone therapy (GAHT) for adolescents with gender dysphoria. This specific combination is being evaluated in a Phase 3, randomized, open-label clinical trial (NCT06351501) sponsored by Assistance Publique - Hôpitaux de Paris. The trial compares the effectiveness of early hormonal treatment (initiated at age 13.5) with standard care (initiated at age 15.5) to improve psychosocial outcomes and quality of life. The regimen involves the administration of either estrogens (such as estradiol topical) for feminizing therapy in individuals assigned male at birth, or testosterone (such as testosterone transdermal gel) for masculinizing therapy in individuals assigned female at birth. These small molecule steroid hormones act as agonists at the estrogen and androgen receptors, respectively, to induce desired secondary sexual characteristics and alleviate the distress associated with gender dysphoria.

Other names

oestrogenes + testosteroneestradiol + testosteronegender-affirming hormone therapyGAHT