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Drug intelligence / Profile preview
ethinyl estradiol + levonorgestrel (Corium)
- Development stage
- Unknown
- Lead developer
- Insud Pharma
- Modality
- Small Molecules
- Administration
- Transdermal
01
Overview
AG200 (specifically AG200-15, marketed as Twirla) is a combined hormonal contraceptive (CHC) transdermal patch developed by Agile Therapeutics in collaboration with Corium. It delivers a daily dose of the estrogen ethinyl estradiol and the progestin levonorgestrel. The patch utilizes the proprietary SKINFUSION technology, a multi-layer drug-in-adhesive system designed to deliver hormones through the skin over a seven-day period. AG200 works primarily by suppressing gonadotropins, which inhibits ovulation and thickens cervical mucus to prevent pregnancy. It was FDA-approved in 2020 for use in women of reproductive potential with a BMI < 30 kg/m². Additional pipeline variations include AG200-ER for extended-cycle regimens and AG200-15 (SmP) for shorter, lighter periods.
- Brand names
- Twirla
- Other names
- AG200-15 TCDSAG-200-15 TCDSAG 200-15 TCDS
02
Targets
ER (Estrogen receptor)PR (Progesterone receptor)
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