ethinylestradiol + dienogest (Zentiva)

Bonadea Plus is a combined oral contraceptive (COC) developed by Zentiva, featuring a low-dose formulation of 0.02 mg ethinylestradiol and 2 mg dienogest administered in a 24+4 day regimen. Ethinylestradiol is a synthetic estrogen that provides cycle control and suppresses follicle-stimulating hormone (FSH), while dienogest is a unique fourth-generation progestin that combines potent progestogenic effects with significant antiandrogenic activity. The 24+4 regimen (24 active tablets followed by 4 placebo tablets) is designed to provide a shorter hormone-free interval compared to traditional 21-day cycles, potentially leading to greater suppression of ovarian activity and improved withdrawal symptom profiles. Its primary mechanism of action is the inhibition of ovulation, supplemented by changes in cervical mucus viscosity and endometrial receptivity. This formulation is distinguished from the standard Bonadea product, which contains a higher dose of ethinylestradiol (0.03 mg) and follows a 21-day schedule.

Brand names

Bonadea Plus

Other names

EE/DNG 0.02/2 mg 24+4