ethinylestradiol + levonorgestrel

**Ethinylestradiol + levonorgestrel** is a fixed-dose combined hormonal contraceptive comprising ethinylestradiol, a synthetic estrogen, and levonorgestrel, a synthetic progestin. It is available in multiple product-specific strengths, cyclic and extended-cycle oral regimens, and as a transdermal system. The principal contraceptive effect is suppression of hypothalamic-pituitary gonadotropin signaling and inhibition of ovulation; progestin-related cervical-mucus thickening and endometrial changes further reduce the likelihood of fertilization and implantation. Products containing this exact active-ingredient pair are approved for prevention of pregnancy, while clinical studies have also evaluated particular formulations for dysmenorrhea, abnormal uterine bleeding, endometriosis-related symptoms, menstrual migraine, premenstrual dysphoric disorder, and other reproductive-endocrine settings. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=44fbc5ae-5682-471f-a12a-955e8b4d233a))

Brand names

AlesseAvianeLessinaLuteraLybrelOrsythiaSeasonaleSronyxTwirlaVienva

Other names

ethinyl estradiol + levonorgestrellevonorgestrel + ethinylestradiollevonorgestrel + ethinyl estradiolEE + LNGLNG + EE