Drug intelligence / Profile preview

ethinylestradiol + levonorgestrel (Bayer)

Development stage
Unknown
Lead developer
Bayer
Modality
Small Molecules
Administration
Oral
01

Overview

MonoStep is a monophasic combined oral contraceptive developed by Jenapharm (a subsidiary of Bayer). It is a fixed-dose combination of the synthetic estrogen ethinylestradiol (30 mcg) and the synthetic progestin levonorgestrel (125 mcg). MonoStep prevents pregnancy primarily by suppressing ovulation through the inhibition of gonadotropin secretion from the pituitary gland. Additionally, it thickens cervical mucus to inhibit sperm penetration and alters the endometrium to prevent implantation. It is administered orally on a 21-day active pill cycle followed by a 7-day pill-free interval.

Brand names
AfirmelleAlesseAlmina 28Almina28Almina-28AltaveraAlysenaAmethiaAmethystAnubisAshlynaAubraAubra EQAva 30 EDAva30 EDAva-30 EDAvianeAyunaBalcoltraBesafeCamreseCamrese LoCecilChatealChateal EQChoiceCretradiolCybelleDayseeDelylaDolishaleDos dias nEleanorEleonoreElifemmeEnpresseErlidonaEvelea mdEvelyn edFalminaFayosimFemexinFemmeFemme tab edFolliminForladyIcleviaImediatIntrovaleJaimiessJolessaJoyeauxKurveloLenest 20 EDLenest20 EDLenest-20 EDLenest 30 EDLenest30 EDLenest-30 EDLessinaLeveretteLevlenLevlen edLevliteLevominLevonestLevoraLevostrolLo/ovralLoetteLoette 28Loette28Loette-28LogynonLogynon EDLoJaimiessLovetteLuteraLybrelMaexeniMarlissaMellevaMicrofem maxMicrogynonMicrogynon 30Microgynon30Microgynon-30Microgynon EDMicronelle edMicrovlarMinisistonMinzoyaMirabellaMiranovaMonoStepMyzilraNordetteNordiolNorfenNorgylenOralconOrsythiaOvreenaOvranettePortiaQuasenseRigevidonSeasonaleSeasoniqueSelinaSelina gynialSelly gynialSetlakinSimpesseSronyxTetragynonTrionettaTriphasilTriquilarTrivoraTwirlaTyblumeVienvaVilora
Other names
EE/LNGethinyl estradiol + levonorgestrelethinylestradiol and levonorgestrelethinylestradiol/levonorgestrellevonorgestrel + ethinylestradiollevonorgestrel and ethinyl estradiol
02

Targets

PR (Progesterone receptor)ESR2 (ERβ)AR (Adrenergic receptors)ESR1 (ERα)

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