Drug intelligence / Profile preview

ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-carboxylate

Development stage
Unknown
Modality
Small Molecules
01

Overview

Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine‑1‑carboxylate is a synthetic small molecule belonging to the class of _piperidinecarboxylic acids_, characterized by a piperidine ring substituted with an ethoxycarbonyl group and a _(4-methylpyridin‑2-yl)amino moiety_[1][3][5]. It has been studied as an experimental compound, notably for its inhibitory activity against nitric oxide synthase isoforms, particularly _inducible nitric oxide synthase (iNOS/NOS2)_, with reported IC50 values in the nanomolar range for iNOS and much weaker inhibition of _endothelial NOS (eNOS/NOS3)_[4][5]. There are no approved therapeutic indications or marketed products containing this compound. Its primary research interest lies in enzyme inhibition relevant to inflammation and related pathologies.

Other names
Ethyl 4-(4-methylpyridin-2-ylamino)piperidine-1-carboxylate4-(4-Methyl-pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester
02

Targets

NOS2 (Nitric Oxide Synthase 2)NOS3 (eNOS)

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