etomidate + fentanyl

Etomidate + fentanyl is a combination of two injectable drugs used for procedural sedation, induction of anesthesia, and analgesia, particularly in procedures such as colonoscopy. *Etomidate* is a short-acting intravenous anesthetic/hypnotic that acts as a GABA-A receptor agonist, producing rapid onset of unconsciousness with minimal cardiovascular and respiratory depression. *Fentanyl* is a potent synthetic opioid agonist at the μ-opioid receptor, providing analgesia and contributing to overall sedation. The combination aims to leverage etomidate’s hemodynamic stability with fentanyl’s potent analgesic effect, reducing dosing requirements for each, decreasing recovery time, and mitigating side effects such as myoclonus. The combination is sometimes used clinically in anesthesia and procedural sedation, and has reportedly been detected together in non-medical settings, though this is not a licensed fixed-dose combination product. Both drugs are on market individually.